Association Browse

Displaying targets 3826 - 3850 of 4175 in total

Name	UniProt ID Gene Name	Species Category Species	Specific function
Protein farnesyltransferase subunit beta	P49356 FNTB	human Homo sapiens	Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding
Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit	P49354 FNTA	human Homo sapiens	Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate
Serine/threonine-protein kinase Chk1	O14757 CHEK1	human Homo sapiens	Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser- 293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK- cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation
Trimethoprim-sensitive dihydrofolate reductase	Q2YY41 dfrB	bacterial Staphylococcus aureus
Tryptase beta-1	Q15661 TPSAB1	human Homo sapiens	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type
Inorganic pyrophosphatase	Q3JUV5 ppa	bacterial Burkholderia pseudomallei
2,3-diketo-5-methylthiopentyl-1-phosphate enolase	Q5L1E2 mtnW	bacterial Geobacillus kaustophilus	Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
Nuclear receptor-interacting protein 1	P48552 NRIP1	human Homo sapiens	Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors
Subtilisin DY	P00781 apr	bacterial Bacillus licheniformis	Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides
SDS hydrolase SdsA1	Q9I5I9 sdsA1	bacterial Pseudomonas aeruginosa
Serine/threonine-protein kinase PLK1	P53350 PLK1	human Homo sapiens	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis
Prostasin	Q16651 PRSS8	human Homo sapiens	Possesses a trypsin-like cleavage specificity
Chymotrypsin-like elastase family member 2A	P08217 CELA2A	human Homo sapiens	Acts upon elastin
1-deoxypentalenic acid 11-beta hydroxylase	Q82IZ1 ptlH	bacterial Streptomyces avermitilis
Genome polyprotein	Q99AU2	viral Hepacivirus Hepatitis C virus subtype 1b
Putative cytochrome P450	Q9KZF5 SCO6998	bacterial Streptomyces coelicolor
Disintegrin and metalloproteinase domain-containing protein 17	P78536 ADAM17	human Homo sapiens	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity)
Histidine ammonia-lyase	Q8GMG0	bacterial Streptomyces globisporus	L-histidine = urocanate + NH(3)
2-hydroxychromene-2-carboxylate isomerase	Q51948 nahD	bacterial Pseudomonas putida	Catalyzes the isomerization of 2-hydroxychromene-2- carboxylate (HCCA) to trans-O-hydroxybenzylidenepyruvate (THBPA). The reaction is reversible
Cytochrome P450	Q83WG3 staP	bacterial Streptomyces sp.
Neutral ceramidase	Q9I596 PA0845	bacterial Pseudomonas aeruginosa	Hydrolyzes the ceramides into sphingosine and free fatty acid at an optimal pH of 8-9
Lipase	P22088 lipA	bacterial Burkholderia cepacia	Catalyzes the hydrolysis of triglycerides
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6 murF	bacterial Streptococcus pneumoniae	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
Receptor-type tyrosine-protein phosphatase beta	P23467 PTPRB	human Homo sapiens	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Uracil-DNA glycosylase	P13051 UNG	human Homo sapiens	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

Displaying targets 3826 - 3850 of 4175 in total