Association Browse
Displaying targets 126 - 150 of 4175 in total
| Name | UniProt ID Gene Name |
Species Category Species |
Specific function |
|---|---|---|---|
| Coagulation factor VIII | P00451  F8 |
human Homo sapiens |
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa |
| Coagulation factor V | P12259 F5 |
human Homo sapiens |
Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin |
| Myeloid cell surface antigen CD33 | P20138 CD33 |
human Homo sapiens |
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) |
| Mucin, TAG-72, tumor associated glycoprotein 72 | |||
| Adenosine | |||
| Growth factor receptor-bound protein 2 | P62993 GRB2 |
human Homo sapiens |
Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death |
| AMBP protein | P02760 AMBP |
human Homo sapiens |
Inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase |
| Vitamin K-dependent protein S | P07225 PROS1 |
human Homo sapiens |
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis |
| Transforming growth factor beta-1 | P01137 TGFB1 |
human Homo sapiens |
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts |
| Vitronectin | P04004 VTN |
human Homo sapiens |
Somatomedin B is a growth hormone-dependent serum factor with protease-inhibiting activity |
| Canalicular multispecific organic anion transporter 1 | Q92887 ABCC2 |
human Homo sapiens |
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter |
| Apolipoprotein E | P02649 APOE |
human Homo sapiens |
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues |
| Platelet factor 4 | P02776 PF4 |
human Homo sapiens |
Platelet factor 4, non-covalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes |
| Ceruloplasmin | P00450 CP |
human Homo sapiens |
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It is involved in iron transport across the cell membrane |
| Thrombomodulin | P07204 THBD |
human Homo sapiens |
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated |
| Integrin beta-3 | P05106 ITGB3 |
human Homo sapiens |
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions |
| Endothelial protein C receptor | Q9UNN8 PROCR |
human Homo sapiens |
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation |
| HLA class II histocompatibility antigen, DQ(6) alpha chain | P01906 HLA-DQA2 |
human Homo sapiens |
|
| Serpin B6 | P35237 SERPINB6 |
human Homo sapiens |
Inhibits thrombin |
| Serum amyloid A protein | P02735 SAA1 |
human Homo sapiens |
Major acute phase reactant. Apolipoprotein of the HDL complex |
| Cytochrome P450 2C9 | P11712 CYP2C9 |
human Homo sapiens |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan |
| UDP-glucuronosyltransferase 1-9 | O60656 UGT1A9 |
human Homo sapiens |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols |
| Indium 111 | |||
| Hyaluronic acid | |||
| HLA class II histocompatibility antigen, DQ beta 1 chain | P01920 HLA-DQB1 |
human Homo sapiens |
Displaying targets 126 - 150 of 4175 in total