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Displaying targets 3951 - 3975 of 4201 in total

Name	UniProt ID Gene Name	Species Category Species	Specific function
Fumarate reductase iron-sulfur subunit	P17596 frdB	bacterial Wolinella succinogenes	The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor
Fumarate reductase cytochrome b subunit	P17413 frdC	bacterial Wolinella succinogenes	The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor
Poly [ADP-ribose] polymerase 3	Q9Y6F1 PARP3	human Homo sapiens	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing
Lactaldehyde dehydrogenase	P25553 aldA	bacterial Escherichia coli	Acts on lactaldehyde as well as other aldehydes
Cytochrome c oxidase subunit 1	P33517 ctaD	bacterial Rhodobacter sphaeroides	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer
Cytochrome c oxidase subunit 2	Q03736 ctaC	bacterial Rhodobacter sphaeroides	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
Nuclear receptor coactivator 5	Q9HCD5 NCOA5	human Homo sapiens	Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC/c-myc in response to 17-beta-estradiol (E2)
Type I polyketide synthase PikAIV	Q9ZGI2 pikAIV	bacterial Streptomyces venezuelae
Putative cytochrome P450 130	Q11062 cyp130	bacterial Mycobacterium tuberculosis
Pol polyprotein	Q88016	viral Primate lentivirus group Simian immunodeficiency virus	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Hemagglutinin	P26137	viral Influenzavirus A Influenza A virus	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore
MAP kinase-activated protein kinase 3	Q16644 MAPKAPK3	human Homo sapiens	Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3
Hydroxymethylglutaryl-CoA synthase, cytoplasmic	Q01581 HMGCS1	human Homo sapiens	This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase
Guanine nucleotide-binding protein G(T) subunit gamma-T1	P63211 GNGT1	human Homo sapiens	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	P62873 GNB1	human Homo sapiens	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction
Phosducin	P20941 PDC	human Homo sapiens	May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism
GTPase KRas	P01116 KRAS	human Homo sapiens	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
Rab proteins geranylgeranyltransferase component A 1	P24386 CHM	human Homo sapiens	Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane
Serine/threonine-protein kinase PCTAIRE-1	Q00536 CDK16	human Homo sapiens	May play a role in signal transduction cascades in terminally differentiated cells
Endo-1,4-beta-xylanase Z	P10478 xynZ	bacterial Clostridium thermocellum	Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans
Est1e	D2YW37	bacterial Clostridium proteoclasticum
Neocarzinostatin	P0A3R9 ncsA	bacterial Streptomyces carzinostaticus	NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non- covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8EBR3 ispF	bacterial Shewanella oneidensis	Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP (By similarity)
Lantibiotic nisin-Z	P29559 nisZ	bacterial Lactococcus lactis subsp.	Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores
D-alanine--D-alanine ligase	Q5HEB7 ddl	bacterial Staphylococcus aureus	Cell wall formation (By similarity)

Displaying targets 3951 - 3975 of 4201 in total