Association Browse
Displaying targets 3976 - 4000 of 4172 in total
| Name | UniProt ID Gene Name |
Species Category Species |
Specific function |
|---|---|---|---|
| Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | P42336  PIK3CA |
human Homo sapiens |
Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2 |
| Genome polyprotein | P23008 |
viral Enterovirus Human rhinovirus 1A |
VP0 precursor is a component of immature procapsids (By similarity) |
| PCZA361.1 | O52791 |
bacterial Amycolatopsis orientalis |
|
| Phospholipase D | P84147 |
bacterial Streptomyces sp. |
|
| Profilin-1 | P07737 PFN1 |
human Homo sapiens |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG |
| Putative uncharacterized protein | Q7Z3Y4 |
human Homo sapiens |
|
| Gag-Pol polyprotein | P04587 gag-pol |
viral Primate lentivirus group Human immunodeficiency virus type 1 group M subtype B |
Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein, Vpr and integrase. This complex is called the pre- integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step, the PIC enters cell nucleus. This process is mediated through integrase and Vpr proteins, and allow the virus to infect a non dividing cell. This ability to enter the nucleus is specific of lentiviruses, other retroviruses cannot and rely on cell division to access cell chromosomes. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The 5'-ends are produced by integrase-catalyzed staggered cuts, 5 bp apart. A Y-shaped, gapped, recombination intermediate results, with the 5'-ends of the viral DNA strands and the 3' ends of target DNA strands remaining unjoined, flanking a gap of 5 bp. The last step is viral DNA integration into host chromosome. This involves host DNA repair synthesis in which the 5 bp gaps between the unjoined strands are filled in and then ligated. Since this process occurs at both cuts flanking the HIV genome, a 5 bp duplication of host DNA is produced at the ends of HIV-1 integration. Alternatively, Integrase may catalyze the excision of viral DNA just after strand transfer, this is termed disintegration (By similarity) |
| 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD | P96851 hsaD |
bacterial Mycobacterium tuberculosis |
|
| Enolase-phosphatase E1 | Q9UHY7 ENOPH1 |
human Homo sapiens |
|
| Glutathione S-transferase (BphK) | Q59721 bphK |
bacterial Burkholderia xenovorans |
|
| Catechol 2,3-dioxygenase | Q0S9X1 RHA1_ro03865 |
bacterial Rhodococcus sp. |
|
| Formate dehydrogenase, nitrate-inducible, major subunit | P24183 fdnG |
bacterial Escherichia coli |
|
| Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit | P0AAJ3 fdnH |
bacterial Escherichia coli |
|
| Formate dehydrogenase, nitrate-inducible, cytochrome b556(fdn) subunit | P0AEK7 fdnI |
bacterial Escherichia coli |
Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556(FDN) component of the formate dehydrogenase |
| NapC/NirT cytochrome c family protein | Q72EF4 DVU_0624 |
bacterial Desulfovibrio vulgaris |
|
| Cytochrome c nitrite reductase, catalytic subunit NfrA, putative | Q72EF3 DVU_0625 |
bacterial Desulfovibrio vulgaris |
Plays a role in nitrite reduction (By similarity) |
| Regulatory protein sdiA | P07026 sdiA |
bacterial Escherichia coli |
Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster |
| Reverse transcriptase/RNaseH | Q72547 pol |
viral Primate lentivirus group Human immunodeficiency virus 1 |
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) |
| Glutamate racemase | Q836J0 murI |
bacterial Enterococcus faecalis |
Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) |
| Dihydrofolate reductase | P0A017 folA |
bacterial Staphylococcus aureus |
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH |
| Ephrin type-A receptor 7 | Q15375 EPHA7 |
human Homo sapiens |
Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5 |
| Calcium/calmodulin-dependent protein kinase type 1G | Q96NX5 CAMK1G |
human Homo sapiens |
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity) |
| cDNA FLJ42801 fis, clone BRCAN2001223, highly similar to Mitogen-activated protein kinase 10 (EC 2.7.11.24) | A6NG28 MAPK10 |
human Homo sapiens |
|
| Kallikrein-7 | P49862 KLK7 |
human Homo sapiens |
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines |
| Probable L-lysine-epsilon aminotransferase | P63509 lat |
bacterial Mycobacterium tuberculosis |
L-lysine + 2-oxoglutarate = 2-aminoadipate 6- semialdehyde + L-glutamate |
Displaying targets 3976 - 4000 of 4172 in total