Association Browse

Displaying targets 101 - 125 of 4201 in total

Name	UniProt ID Gene Name	Species Category Species	Specific function
High affinity immunoglobulin epsilon receptor subunit alpha	P12319 FCER1A	human Homo sapiens	Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines
Collagen alpha-1(I) chain	P02452 COL1A1	human Homo sapiens	Type I collagen is a member of group I collagen (fibrillar forming collagen)
Growth hormone receptor	P10912 GHR	human Homo sapiens	Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling
Prolactin receptor	P16471 PRLR	human Homo sapiens	This is a receptor for the anterior pituitary hormone prolactin
Integrin alpha-IIb	P08514 ITGA2B	human Homo sapiens	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface
Glucagon receptor	P47871 GCGR	human Homo sapiens	This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system
Cytosolic phospholipase A2	P47712 PLA2G4A	human Homo sapiens	Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response
Uric acid
Glucagon-like peptide 1 receptor	P43220 GLP1R	human Homo sapiens	This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Toll-like receptor 2	O60603 TLR2	human Homo sapiens	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6
Neuropilin-1	O14786 NRP1	human Homo sapiens	The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity
Collagen alpha-1(III) chain	P02461 COL3A1	human Homo sapiens	Collagen type III occurs in most soft connective tissues along with type I collagen
Basic fibroblast growth factor receptor 1	P11362 FGFR1	human Homo sapiens	Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)
Fibroblast growth factor receptor 3	P22607 FGFR3	human Homo sapiens	Receptor for acidic and basic fibroblast growth factors. Preferentially binds FGF1
Glucagon-like peptide 2 receptor	O95838 GLP2R	human Homo sapiens	This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Vesicle-associated membrane protein 1	P23763 VAMP1	human Homo sapiens	Involved in the targeting and/or fusion of transport vesicles to their target membrane
Vesicle-associated membrane protein 2	P63027 VAMP2	human Homo sapiens	Involved in the targeting and/or fusion of transport vesicles to their target membrane
Synaptotagmin-2	Q8N9I0 SYT2	human Homo sapiens	May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone
High affinity immunoglobulin epsilon receptor subunit beta	Q01362 MS4A2	human Homo sapiens	Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines
Collagen alpha-1(II) chain	P02458 COL2A1	human Homo sapiens	Collagen type II is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces
Collagen alpha-2(I) chain	P08123 COL1A2	human Homo sapiens	Type I collagen is a member of group I collagen (fibrillar forming collagen)
Xanthine dehydrogenase/oxidase	P47989 XDH	human Homo sapiens	This enzyme can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups
Cytochrome P450 3A4	P08684 CYP3A4	human Homo sapiens	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide
Cytochrome P450 2E1	P05181 CYP2E1	human Homo sapiens	Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms
Glucosylceramide

Displaying targets 101 - 125 of 4201 in total