Association Browse
Displaying targets 26 - 50 of 4170 in total
| Name | UniProt ID Gene Name |
Species Category Species |
Specific function |
|---|---|---|---|
| Lutropin-choriogonadotropic hormone receptor | P22888  LHCGR |
human Homo sapiens |
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase |
| Plasminogen | P00747 PLG |
human Homo sapiens |
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo |
| Plasminogen activator inhibitor 1 | P05121 SERPINE1 |
human Homo sapiens |
This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis |
| Secretin receptor | P47872 SCTR |
human Homo sapiens |
This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase |
| Leukocyte elastase | P08246 ELANE |
human Homo sapiens |
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis |
| Calcitonin receptor | P30988 CALCR |
human Homo sapiens |
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin |
| Thyrotropin receptor | P16473 TSHR |
human Homo sapiens |
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5) |
| Fibrinogen alpha chain | P02671 FGA |
human Homo sapiens |
Fibrinogen has a double function:yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation |
| Growth hormone-releasing hormone receptor | Q02643 GHRHR |
human Homo sapiens |
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion |
| Granulocyte-macrophage colony-stimulating factor receptor alpha chain | P15509 CSF2RA |
human Homo sapiens |
Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells |
| Erythropoietin receptor | P19235 EPOR |
human Homo sapiens |
Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling |
| Urokinase plasminogen activator surface receptor | Q03405 PLAUR |
human Homo sapiens |
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form |
| Granulocyte colony-stimulating factor receptor | Q99062 CSF3R |
human Homo sapiens |
Receptor for granulocyte colony-stimulating factor. In addition it may function in some adhesion or recognition events at the cell surface |
| Asparagine | |||
| Urokinase-type plasminogen activator | P00749 PLAU |
human Homo sapiens |
Specifically cleave the zymogen plasminogen to form the active enzyme plasmin |
| Low-density lipoprotein receptor-related protein 2 | P98164 LRP2 |
human Homo sapiens |
May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release |
| Plasminogen activator inhibitor 2 | P05120 SERPINB2 |
human Homo sapiens |
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1 |
| Interleukin-3 receptor alpha chain | P26951 IL3RA |
human Homo sapiens |
This is a receptor for interleukin-3 |
| Tissue-type plasminogen activator | P00750 PLAT |
human Homo sapiens |
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration |
| Suppressor of tumorigenicity protein 14 | Q9Y5Y6 ST14 |
human Homo sapiens |
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site |
| Plasma serine protease inhibitor | P05154 SERPINA5 |
human Homo sapiens |
Inhibits activated protein C as well as plasminogen activators |
| Nidogen-1 | P14543 NID1 |
human Homo sapiens |
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions |
| Bone-marrow proteoglycan | P13727 PRG2 |
human Homo sapiens |
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA |
| Cytokine receptor common beta chain | P32927 CSF2RB |
human Homo sapiens |
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor |
| Syndecan-2 | P34741 SDC2 |
human Homo sapiens |
Cell surface proteoglycan that bears heparan sulfate |
Displaying targets 26 - 50 of 4170 in total