Reaction: Amiodarone to 1 product

Reaction
Amiodarone
DB01118
Desethylamiodarone
DBMET00012
Reaction type
N-deethylation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
  2. Ha HR, Bigler L, Binder M, Kozlik P, Stieger B, Hesse M, Altorfer HR, Follath F: Metabolism of amiodarone (part I): identification of a new hydroxylated metabolite of amiodarone. Drug Metab Dispos. 2001 Feb;29(2):152-8. [Article]
  3. Chloroquine - Drug Summary - Prescribers Digital Reference - Drug Interactions [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C9Not AvailableNot Availableconfirmed
Cytochrome P450 1A2Not AvailableNot Availableconfirmed
Cytochrome P450 2D6Not AvailableNot Availableconfirmed
Cytochrome P450 2C8Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableconfirmed