Reaction: UK-215,364 to 1 product

Reaction
UK-215,364
DBMET01186
    Voriconazole O-glucuronide derivative (1)
    DBMET01187
    Reaction type
    oxidative defluorination
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    Yes
    Activity
    unknown
    References
    1. Roffey SJ, Cole S, Comby P, Gibson D, Jezequel SG, Nedderman AN, Smith DA, Walker DK, Wood N: The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human. Drug Metab Dispos. 2003 Jun;31(6):731-41. [Article]
    2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
    Comments
    Not Available
    Enzymes
    Not Available