Reaction: Zolpidem to 1 product

Reaction
Zolpidem
DB00425
Methoxyzolpidem derivative (M4)
DBMET01239
Reaction type
methyl-hydroxylation; oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Reidy L, Nolan B, Ramos AR, Walls HC, Steele BW: Zolpidem urine excretion profiles and cross-reactivity with ELISA((R)) kits in subjects using Zolpidem or Ambien((R)) CR as a prescription sleep aid. J Anal Toxicol. 2011 Jun;35(5):294-301. [Article]
  2. Pichard L, Gillet G, Bonfils C, Domergue J, Thenot JP, Maurel P: Oxidative metabolism of zolpidem by human liver cytochrome P450S. Drug Metab Dispos. 1995 Nov;23(11):1253-62. [Article]
  3. Pharmacotherapy of Insomnia: Focus on Zolpidem Extended Release [File]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 1A2Not AvailableNot Availableconfirmed
Cytochrome P450 2D6Not AvailableNot Availableconfirmed