Reaction: ortho-hydroxyatorvastatin to 1 product

Reaction
Reaction type
lactonization
Direction
Not Available
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
inactive
References
  1. Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U: Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos. 2000 Nov;28(11):1369-78. [Article]
  2. Hermann M, Bogsrud MP, Molden E, Asberg A, Mohebi BU, Ose L, Retterstol K: Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy. Clin Pharmacol Ther. 2006 Jun;79(6):532-9. [Article]
  3. Lennernas H: Clinical pharmacokinetics of atorvastatin. Clin Pharmacokinet. 2003;42(13):1141-60. [Article]
Comments
Not Available
Enzymes
Not Available