Reaction: Dapagliflozin to 1 product

Reaction
Dapagliflozin
DB06292
Dapagliflozin 3-O-glucuronide
DBMET01372
Reaction type
glucuronidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
inactive
References
  1. Kasichayanula S, Chang M, Hasegawa M, Liu X, Yamahira N, LaCreta FP, Imai Y, Boulton DW: Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in Japanese subjects without and with type 2 diabetes mellitus. Diabetes Obes Metab. 2011 Apr;13(4):357-65. doi: 10.1111/j.1463-1326.2011.01359.x. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-9Not AvailableNot Availableconfirmed