Reaction: Tretinoin to 1 product

Reaction
Reaction type
hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Marill J, Idres N, Capron CC, Nguyen E, Chabot GG: Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab. 2003 Feb;4(1):1-10. doi: 10.2174/1389200033336900. [Article]
  2. Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. [Article]
  3. Marill J, Capron CC, Idres N, Chabot GG: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids. Biochem Pharmacol. 2002 Mar 1;63(5):933-43. doi: 10.1016/s0006-2952(01)00925-x. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C8Not AvailableNot Availableimplied
Cytochrome P450 3A7Not AvailableNot Availableimplied
Cytochrome P450 4A11Not AvailableNot Availableimplied
Cytochrome P450 2B6Not AvailableNot Availableimplied
Cytochrome P450 2A6Not AvailableNot Availableimplied
Cytochrome P450 2C9Not AvailableNot Availableimplied
Cytochrome P450 2C18Not AvailableNot Availableimplied
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 3A5Not AvailableNot Availableimplied