Reaction: Amitriptyline to 1 product
- Reaction
- Reaction type
- N-demethylation
- Direction
- Not Available
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- active
- References
- Breyer-Pfaff U: The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man. Drug Metab Rev. 2004 Oct;36(3-4):723-46. doi: 10.1081/DMR-200033482 . [Article]
- Zhou X, Chen C, Zhang F, Zhang Y, Feng Y, Ouyang H, Xu Y, Jiang H: Metabolism and bioactivation of the tricyclic antidepressant amitriptyline in human liver microsomes and human urine. Bioanalysis. 2016 Jul;8(13):1365-81. doi: 10.4155/bio-2016-0025. Epub 2016 Jun 9. [Article]
- Ryu S, Park S, Lee JH, Kim YR, Na HS, Lim HS, Choi HY, Hwang IY, Lee JG, Park ZW, Oh WY, Kim JM, Choi SE: A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans. Clin Transl Sci. 2017 Mar;10(2):93-101. doi: 10.1111/cts.12451. Epub 2017 Mar 14. [Article]
- Olesen OV, Linnet K: Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes. Pharmacology. 1997 Nov;55(5):235-43. doi: 10.1159/000139533. [Article]
- Amitriptyline FDA label [File]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C9 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available confirmed Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 3A4 Not Available Not Available confirmed Cytochrome P450 2D6 Not Available Not Available implied Cytochrome P450 2B6 Not Available Not Available implied Cytochrome P450 2C8 Not Available Not Available implied