Reaction: Voriconazole to 1 product

Reaction
Voriconazole
DB00582
Voriconazole N-Oxide
DBMET00071
Reaction type
Not Available
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H: Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6. doi: 10.1016/j.bcp.2007.03.012. Epub 2007 Mar 19. [Article]
  2. Roffey SJ, Cole S, Comby P, Gibson D, Jezequel SG, Nedderman AN, Smith DA, Walker DK, Wood N: The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human. Drug Metab Dispos. 2003 Jun;31(6):731-41. [Article]
  3. VFENDⓇ FDA Label [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C9Not AvailableNot Availableconfirmed
Cytochrome P450 2C19Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 3A5Not AvailableNot Availableconfirmed
Cytochrome P450 3A7Not AvailableNot Availableconfirmed