Flecainide acetateProduct ingredient for Flecainide
- Name
- Flecainide acetate
- Drug Entry
- Flecainide
Flecainide is a Class I anti-arrhythmic agent like encainide and propafenone.7 Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics.10 It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.12,13
Flecainide was granted FDA approval on 31 October 1985.11
- Accession Number
- DBSALT000086
- Structure
- Synonyms
- Flecainide monoacetate / N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate
- External IDs
- R 818 / R-818
- UNII
- M8U465Q1WQ
- CAS Number
- 54143-56-5
- Weight
- Average: 474.3947
Monoisotopic: 474.158941118 - Chemical Formula
- C19H24F6N2O5
- InChI Key
- RKXNZRPQSOPPRN-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)
- IUPAC Name
- N-[(piperidin-2-yl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide; acetic acid
- SMILES
- CC(O)=O.FC(F)(F)COC1=CC(C(=O)NCC2CCCCN2)=C(OCC(F)(F)F)C=C1
- External Links
- KEGG Drug
- D00638
- PubChem Compound
- 41022
- ChemSpider
- 37445
- ChEBI
- 5091
- ChEMBL
- CHEMBL1200822
- Wikipedia
- Flecainide
- Predicted Properties
Property Value Source Water Solubility 0.0324 mg/mL ALOGPS logP 2.98 ALOGPS logP 3.19 Chemaxon logS -4.1 ALOGPS pKa (Strongest Acidic) 13.68 Chemaxon pKa (Strongest Basic) 9.62 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 59.59 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 88.4 m3·mol-1 Chemaxon Polarizability 35.76 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon