Fospropofol disodiumProduct ingredient for Fospropofol
- Name
- Fospropofol disodium
- Drug Entry
- Fospropofol
Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent. Unlike propofol, does not cause injection-site pain as it is unable to activate TRPA1. FDA approved in December 2008. Fospropofol is a Schedule IV controlled substance in the United States under the Controlled Substances Act.
- Accession Number
- DBSALT000090
- Structure
Structure for Fospropofol disodium (DBSALT000090)
- Synonyms
- (2,6-bis(1-methylethyl)phenoxy)methyl disodium phosphate / 2,6-diisopropylphenoxymethyl phosphate,disodium salt / Fospropofol disodium salt / Fospropofol sodium
- UNII
- 30868AY0IF
- CAS Number
- 258516-87-9
- Weight
- Average: 332.2403
Monoisotopic: 332.07654958 - Chemical Formula
- C13H19Na2O5P
- InChI Key
- LWYLQNWMSGFCOZ-UHFFFAOYSA-L
- InChI
- InChI=1S/C13H21O5P.2Na/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16;;/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16);;/q;2*+1/p-2
- IUPAC Name
- disodium [2,6-bis(propan-2-yl)phenoxy]methyl phosphate
- SMILES
- [Na+].[Na+].CC(C)C1=CC=CC(C(C)C)=C1OCOP([O-])([O-])=O
- External Links
- Human Metabolome Database
- HMDB0015661
- PubChem Compound
- 3038497
- ChemSpider
- 2302061
- ChEMBL
- CHEMBL2021422
- PharmGKB
- PA165958389
- Wikipedia
- Fospropofol
- Predicted Properties
Property Value Source Water Solubility 1.71 mg/mL ALOGPS logP 3.31 ALOGPS logP 3.6 Chemaxon logS -2.3 ALOGPS pKa (Strongest Acidic) 1.44 Chemaxon pKa (Strongest Basic) -5 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 81.65 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 70.63 m3·mol-1 Chemaxon Polarizability 28.52 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon