Guvacine hydrochlorideProduct ingredient for Guvacine
- Name
- Guvacine hydrochloride
- Drug Entry
- Guvacine
Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine. Currently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant affinity at GABA receptors.
- Accession Number
- DBSALT000094
- Structure
Structure for Guvacine hydrochloride (DBSALT000094)
- Synonyms
- Not Available
- UNII
- Not Available
- CAS Number
- Not Available
- Weight
- Average: 163.602
Monoisotopic: 163.040006276 - Chemical Formula
- C6H10ClNO2
- InChI Key
- FGNUNVVTHHKDAM-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H9NO2.ClH/c8-6(9)5-2-1-3-7-4-5;/h2,7H,1,3-4H2,(H,8,9);1H
- IUPAC Name
- 1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
- SMILES
- Cl.OC(=O)C1=CCCNC1
- External Links
- PubChem Compound
- 11957555
- ChemSpider
- 10131803
- ChEBI
- 805348
- ChEMBL
- CHEMBL1256362
- Predicted Properties
Property Value Source Water Solubility 30.8 mg/mL ALOGPS logP -2.2 ALOGPS logP -2.6 Chemaxon logS -0.62 ALOGPS pKa (Strongest Acidic) 3.57 Chemaxon pKa (Strongest Basic) 9.77 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 49.33 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 33.8 m3·mol-1 Chemaxon Polarizability 12.84 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon