Propafenone hydrochlorideProduct ingredient for Propafenone
- Name
- Propafenone hydrochloride
- Drug Entry
- Propafenone
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
- Accession Number
- DBSALT000148
- Structure
Structure for Propafenone hydrochloride (DBSALT000148)
- Synonyms
- Propafenone HCl
- UNII
- 33XCH0HOCD
- CAS Number
- 34183-22-7
- Weight
- Average: 377.905
Monoisotopic: 377.175771474 - Chemical Formula
- C21H28ClNO3
- InChI Key
- XWIHRGFIPXWGEF-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
- IUPAC Name
- 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one hydrochloride
- SMILES
- Cl.CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1
- External Links
- PubChem Compound
- 36708
- ChemSpider
- 33715
- ChEBI
- 8466
- ChEMBL
- CHEMBL1201063
- Wikipedia
- Propafenone
- Predicted Properties
Property Value Source Water Solubility 0.00758 mg/mL ALOGPS logP 3.1 ALOGPS logP 3.54 Chemaxon logS -4.6 ALOGPS pKa (Strongest Acidic) 14.09 Chemaxon pKa (Strongest Basic) 9.72 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 58.56 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 100.21 m3·mol-1 Chemaxon Polarizability 39.46 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon