Tenofovir disoproxil fumarateProduct ingredient for Tenofovir disoproxil

Name
Tenofovir disoproxil fumarate
Drug Entry
Tenofovir disoproxil

Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 Label.

Accession Number
DBSALT000172
Structure
Synonyms
Not Available
UNII
OTT9J7900I
CAS Number
202138-50-9
Weight
Average: 635.5149
Monoisotopic: 635.183987333
Chemical Formula
C23H34N5O14P
InChI Key
VCMJCVGFSROFHV-WZGZYPNHSA-N
InChI
InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1
IUPAC Name
(2E)-but-2-enedioic acid; bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonate
SMILES
[H]\C(=C(\[H])C(O)=O)C(O)=O.[H][C@@](C)(CN1C=NC2=C(N)N=CN=C12)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C
KEGG Drug
D01982
PubChem Compound
6398764
ChemSpider
4911265
ChEBI
63718
ChEMBL
CHEMBL1486
Wikipedia
Tenofovir_disoproxil
Predicted Properties
PropertyValueSource
Water Solubility0.712 mg/mLALOGPS
logP-0.02ALOGPS
logP2.65Chemaxon
logS-2.9ALOGPS
pKa (Strongest Acidic)18.55Chemaxon
pKa (Strongest Basic)3.74Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count10Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area185.44 Å2Chemaxon
Rotatable Bond Count19Chemaxon
Refractivity118.59 m3·mol-1Chemaxon
Polarizability48.94 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon