Tetraethylammonium hydroxideProduct ingredient for Tetraethylammonium

Name
Tetraethylammonium hydroxide
Drug Entry
Tetraethylammonium

Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide. Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. Because of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels. Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium.

Accession Number
DBSALT000176
Structure
Synonyms
Not Available
UNII
RA8VU41B1F
CAS Number
77-98-5
Weight
Average: 147.2584
Monoisotopic: 147.162314299
Chemical Formula
C8H21NO
InChI Key
LRGJRHZIDJQFCL-UHFFFAOYSA-M
InChI
InChI=1S/C8H20N.H2O/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H2/q+1;/p-1
IUPAC Name
tetraethylazanium hydroxide
SMILES
[OH-].CC[N+](CC)(CC)CC
PubChem Compound
6509
ChemSpider
6263
Wikipedia
Tetraethylammonium_hydroxide
Predicted Properties
PropertyValueSource
Water Solubility0.783 mg/mLALOGPS
logP0.16ALOGPS
logP-2.5Chemaxon
logS-2.3ALOGPS
Physiological Charge1Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity54.9 m3·mol-1Chemaxon
Polarizability17.32 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon