Terbutaline sulfateProduct ingredient for Terbutaline
- Name
- Terbutaline sulfate
- Drug Entry
- Terbutaline
Terbutaline was first synthesized in 196612 and described in the literature in the late 1960s and early 1970s.11 It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.12,16,17
Terbutaline was granted FDA approval on 25 March 1974.15
- Accession Number
- DBSALT000297 (DBSALT002968)
- Structure
Structure for Terbutaline sulfate (DBSALT000297)
- Synonyms
- Terbutaline hemisulfate / Terbutaline hemisulfate salt / Terbutaline sulfate / Terbutaline sulphate
- External IDs
- KWD-2019
- UNII
- 576PU70Y8E
- CAS Number
- 23031-32-5
- Weight
- Average: 548.65
Monoisotopic: 548.24036667 - Chemical Formula
- C24H40N2O10S
- InChI Key
- KFVSLSTULZVNPG-UHFFFAOYSA-N
- InChI
- InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
- IUPAC Name
- bis(5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol); sulfuric acid
- SMILES
- OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1
- External Links
- PubChem Compound
- 657301
- ChemSpider
- 29323
- ChEBI
- 9450
- ChEMBL
- CHEMBL1315867
- Wikipedia
- Terbutaline
- Predicted Properties
Property Value Source Water Solubility 5.84 mg/mL ALOGPS logP 0.55 ALOGPS logP 0.44 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 8.86 Chemaxon pKa (Strongest Basic) 9.76 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 72.72 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 63.04 m3·mol-1 Chemaxon Polarizability 24.86 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon