Sotalol hydrochlorideProduct ingredient for Sotalol
- Name
- Sotalol hydrochloride
- Drug Entry
- Sotalol
Sotalol is a methanesulfonanilide developed in 1960.6 It was the first of the class III anti arrhythmic drugs.6 Sotalol was first approved as an oral tablet on 30 October 1992.8 A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm in atrial fibrillation or flutter.Label,9,10
- Accession Number
- DBSALT000318
- Structure
- Synonyms
- Sotalol HCl
- UNII
- HEC37C70XX
- CAS Number
- 959-24-0
- Weight
- Average: 308.825
Monoisotopic: 308.096140945 - Chemical Formula
- C12H21ClN2O3S
- InChI Key
- VIDRYROWYFWGSY-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
- IUPAC Name
- N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide hydrochloride
- SMILES
- Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1
- External Links
- PubChem Compound
- 66245
- ChemSpider
- 59630
- ChEBI
- 9207
- ChEMBL
- CHEMBL1700
- Wikipedia
- Sotalol
- Predicted Properties
Property Value Source Water Solubility 0.782 mg/mL ALOGPS logP 0.85 ALOGPS logP -0.4 Chemaxon logS -2.5 ALOGPS pKa (Strongest Acidic) 10.07 Chemaxon pKa (Strongest Basic) 9.43 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 78.43 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 71.12 m3·mol-1 Chemaxon Polarizability 29.34 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon