Terazosin hydrochlorideProduct ingredient for Terazosin

Name
Terazosin hydrochloride
Drug Entry
Terazosin

Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertensionLabel1. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate2.

Accession Number
DBSALT000326
Structure
Synonyms
Terazosin HCl / Terazosin HCl anhydrous / Terazosin hydrochloride anhydrous
UNII
8QOP8Z9955
CAS Number
63074-08-8
Weight
Average: 423.894
Monoisotopic: 423.167332052
Chemical Formula
C19H26ClN5O4
InChI Key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
InChI
InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
IUPAC Name
6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-imine hydrochloride
SMILES
Cl.COC1=C(OC)C=C2C(=N)NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1
PubChem Compound
44383
ChemSpider
40382
ChEMBL
CHEMBL1256665
Wikipedia
Terazosin
Predicted Properties
PropertyValueSource
Water Solubility0.132 mg/mLALOGPS
logP0.77ALOGPS
logP0.053Chemaxon
logS-3.5ALOGPS
pKa (Strongest Acidic)11.09Chemaxon
pKa (Strongest Basic)13.32Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count8Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area99.48 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity115.72 m3·mol-1Chemaxon
Polarizability41.65 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon