Moexipril HydrochlorideProduct ingredient for Moexipril
- Name
- Moexipril Hydrochloride
- Drug Entry
- Moexipril
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
- Accession Number
- DBSALT000504
- Structure
- Synonyms
- Moexipril HCl
- UNII
- Q1UMG3UH45
- CAS Number
- 82586-52-5
- Weight
- Average: 535.029
Monoisotopic: 534.213279191 - Chemical Formula
- C27H35ClN2O7
- InChI Key
- JXRAXHBVZQZSIC-JKVLGAQCSA-N
- InChI
- InChI=1S/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1
- IUPAC Name
- (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
- SMILES
- Cl.[H][C@@](C)(N[C@@]([H])(CCC1=CC=CC=C1)C(=O)OCC)C(=O)N1CC2=CC(OC)=C(OC)C=C2C[C@@]1([H])C(O)=O
- External Links
- PubChem Compound
- 54889
- ChemSpider
- 49563
- ChEBI
- 6961
- ChEMBL
- CHEMBL1200534
- Predicted Properties
Property Value Source Water Solubility 0.00585 mg/mL ALOGPS logP 1.52 ALOGPS logP 1.5 Chemaxon logS -4.9 ALOGPS pKa (Strongest Acidic) 3.46 Chemaxon pKa (Strongest Basic) 5.2 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 114.4 Å2 Chemaxon Rotatable Bond Count 12 Chemaxon Refractivity 132.88 m3·mol-1 Chemaxon Polarizability 53.51 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon