Guanfacine hydrochlorideProduct ingredient for Guanfacine

Show full entry for Guanfacine
Name
Guanfacine hydrochloride
Drug Entry
Guanfacine

Guanfacine, or BS 100-141,8,9 is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension10 but is now indicated as an extended release tablet for the treatment of ADHD.11 Guanfacine was first described in the literature in 1974.9

Guanfacine was granted FDA approval on 27 October 1986.10

See full entry for Guanfacine
Accession Number
DBSALT000509
Structure
Similar Structures
Synonyms
Guanfacine HCl / Guanfacine hydrochloride
External IDs
BS 100-141 / LON 798
UNII
PML56A160O
CAS Number
29110-48-3
Weight
Average: 282.554
Monoisotopic: 280.988945078
Chemical Formula
C9H10Cl3N3O
InChI Key
DGFYECXYGUIODH-UHFFFAOYSA-N
InChI
InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
IUPAC Name
N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride
SMILES
Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl
PubChem Compound
71401
ChemSpider
64493
ChEBI
5559
ChEMBL
CHEMBL1200494
Wikipedia
Guanfacine
Predicted Properties
PropertyValueSource
Water Solubility0.139 mg/mLALOGPS
logP2.28ALOGPS
logP1.74Chemaxon
logS-3.2ALOGPS
pKa (Strongest Acidic)11.64Chemaxon
pKa (Strongest Basic)8.65Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area78.97 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity69.63 m3·mol-1Chemaxon
Polarizability22.44 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon