Acetazolamide sodiumProduct ingredient for Acetazolamide

Name
Acetazolamide sodium
Drug Entry
Acetazolamide

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Accession Number
DBSALT000539
Structure
Synonyms
Not Available
UNII
429ZT169UH
CAS Number
1424-27-7
Weight
Average: 244.227
Monoisotopic: 243.970076101
Chemical Formula
C4H5N4NaO3S2
InChI Key
MRSXAJAOWWFZJJ-UHFFFAOYSA-M
InChI
InChI=1S/C4H6N4O3S2.Na/c1-2(9)6-3-7-8-4(12-3)13(5,10)11;/h1H3,(H3,5,6,7,9,10,11);/q;+1/p-1
IUPAC Name
sodium N-acetyl-5-sulfamoyl-1,3,4-thiadiazol-2-aminide
SMILES
[Na+].CC(=O)[N-]C1=NN=C(S1)S(N)(=O)=O
PubChem Compound
13290219
ChemSpider
14297
ChEBI
31163
ChEMBL
CHEMBL1200814
Wikipedia
Acetazolamide
Predicted Properties
PropertyValueSource
Water Solubility6.47 mg/mLALOGPS
logP-0.65ALOGPS
logP-1Chemaxon
logS-1.6ALOGPS
pKa (Strongest Acidic)6.55Chemaxon
pKa (Strongest Basic)-3.3Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area112.24 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity44.78 m3·mol-1Chemaxon
Polarizability18.72 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon