Tizanidine hydrochlorideProduct ingredient for Tizanidine
- Name
- Tizanidine hydrochloride
- Drug Entry
- Tizanidine
Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury 9. It may also be caused by musculoskeletal injury 5. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition.
Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm Label.
- Accession Number
- DBSALT000550
- Structure
Structure for Tizanidine hydrochloride (DBSALT000550)
- Synonyms
- Tizanidine HCl
- UNII
- B53E3NMY5C
- CAS Number
- 64461-82-1
- Weight
- Average: 290.172
Monoisotopic: 288.995571417 - Chemical Formula
- C9H9Cl2N5S
- InChI Key
- ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
- IUPAC Name
- 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
- SMILES
- Cl.ClC1=C(NC2=NCCN2)C2=NSN=C2C=C1
- External Links
- PubChem Compound
- 114869
- ChemSpider
- 102826
- ChEBI
- 9609
- ChEMBL
- CHEMBL1200329
- Wikipedia
- Tizanidine
- Predicted Properties
Property Value Source Water Solubility 0.133 mg/mL ALOGPS logP 1.6 ALOGPS logP 2.02 Chemaxon logS -3.3 ALOGPS pKa (Strongest Basic) 7.49 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 62.2 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 64.77 m3·mol-1 Chemaxon Polarizability 23.99 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon