Dicyclomine hydrochlorideProduct ingredient for Dicyclomine
- Name
- Dicyclomine hydrochloride
- Drug Entry
- Dicyclomine
Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.3,4,5,6 Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.7
Dicyclomine was granted FDA approval on 11 May 1950.6
- Accession Number
- DBSALT000698
- Structure
- Synonyms
- Dicyclomine HCl / Dicyclomine hydrochloride / Dicycloverine hydrochloride
- UNII
- CQ903KQA31
- CAS Number
- 67-92-5
- Weight
- Average: 345.948
Monoisotopic: 345.243457108 - Chemical Formula
- C19H36ClNO2
- InChI Key
- GUBNMFJOJGDCEL-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
- IUPAC Name
- 2-(diethylamino)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate hydrochloride
- SMILES
- Cl.CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
- External Links
- PubChem Compound
- 441344
- ChemSpider
- 390099
- ChEBI
- 4515
- ChEMBL
- CHEMBL1200479
- Wikipedia
- Dicycloverine
- Predicted Properties
Property Value Source Water Solubility 0.00327 mg/mL ALOGPS logP 5.82 ALOGPS logP 4.93 Chemaxon logS -5 ALOGPS pKa (Strongest Basic) 8.96 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 29.54 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 91.78 m3·mol-1 Chemaxon Polarizability 37.96 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon