Dicyclomine hydrochlorideProduct ingredient for Dicyclomine

Name
Dicyclomine hydrochloride
Drug Entry
Dicyclomine

Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.3,4,5,6 Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.7

Dicyclomine was granted FDA approval on 11 May 1950.6

Accession Number
DBSALT000698
Structure
Synonyms
Dicyclomine HCl / Dicyclomine hydrochloride / Dicycloverine hydrochloride
UNII
CQ903KQA31
CAS Number
67-92-5
Weight
Average: 345.948
Monoisotopic: 345.243457108
Chemical Formula
C19H36ClNO2
InChI Key
GUBNMFJOJGDCEL-UHFFFAOYSA-N
InChI
InChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
IUPAC Name
2-(diethylamino)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate hydrochloride
SMILES
Cl.CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
PubChem Compound
441344
ChemSpider
390099
ChEBI
4515
ChEMBL
CHEMBL1200479
Wikipedia
Dicycloverine
Predicted Properties
PropertyValueSource
Water Solubility0.00327 mg/mLALOGPS
logP5.82ALOGPS
logP4.93Chemaxon
logS-5ALOGPS
pKa (Strongest Basic)8.96Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area29.54 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity91.78 m3·mol-1Chemaxon
Polarizability37.96 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon