Zuclopenthixol decanoateProduct ingredient for Zuclopenthixol
- Name
- Zuclopenthixol decanoate
- Drug Entry
- Zuclopenthixol
Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound belongs to the thioxanthenes. These are organic polycyclic compounds containing a thioxanthene moiety, which is an aromatic tricycle derived from xanthene by replacing the oxygen atom with a sulfur atom. Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor, D(2) dopamine receptor, D(1A) dopamine receptor, and alpha-1A adrenergic receptor. It is known that zuclopenthixol is metabolized by Cytochrome P450 2D6. Zuclopenthixol was approved for use in Canada in 2011, but is not approved for use in the United States.
- Accession Number
- DBSALT000787
- Structure
Structure for Zuclopenthixol decanoate (DBSALT000787)
- Synonyms
- Not Available
- UNII
- TSS9KIZ5OG
- CAS Number
- 64053-00-5
- Weight
- Average: 555.214
Monoisotopic: 554.273377027 - Chemical Formula
- C32H43ClN2O2S
- InChI Key
- QRUAPADZILXULG-WKIKZPBSSA-N
- InChI
- InChI=1S/C32H43ClN2O2S/c1-2-3-4-5-6-7-8-15-32(36)37-24-23-35-21-19-34(20-22-35)18-11-13-27-28-12-9-10-14-30(28)38-31-17-16-26(33)25-29(27)31/h9-10,12-14,16-17,25H,2-8,11,15,18-24H2,1H3/b27-13-
- IUPAC Name
- 2-(4-{3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethyl decanoate
- SMILES
- [H]\C(CCN1CCN(CCOC(=O)CCCCCCCCC)CC1)=C1/C2=CC=CC=C2SC2=C1C=C(Cl)C=C2
- External Links
- PubChem Compound
- 6450333
- ChemSpider
- 4952942
- ChEBI
- 177690
- ZINC
- ZINC000056898828
- Wikipedia
- Zuclopenthixol
- Predicted Properties
Property Value Source Water Solubility 3.41e-05 mg/mL ALOGPS logP 7.46 ALOGPS logP 8.48 Chemaxon logS -7.2 ALOGPS pKa (Strongest Basic) 7.84 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 32.78 Å2 Chemaxon Rotatable Bond Count 15 Chemaxon Refractivity 172.99 m3·mol-1 Chemaxon Polarizability 65.73 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon