Hydralazine hydrochlorideProduct ingredient for Hydralazine
- Name
- Hydralazine hydrochloride
- Drug Entry
- Hydralazine
Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed.15 Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.10,19,20 Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.17
Hydralazine hydrochloride was FDA approved on 15 January 1953.18
- Accession Number
- DBSALT000792
- Structure
Structure for Hydralazine hydrochloride (DBSALT000792)
- Synonyms
- Hydralazine HCl
- UNII
- FD171B778Y
- CAS Number
- 304-20-1
- Weight
- Average: 196.637
Monoisotopic: 196.051574015 - Chemical Formula
- C8H9ClN4
- InChI Key
- ZUXNZUWOTSUBMN-UHFFFAOYSA-N
- InChI
- InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
- IUPAC Name
- 1-hydrazinylidene-1,2-dihydrophthalazine hydrochloride
- SMILES
- Cl.NN=C1NN=CC2=CC=CC=C12
- External Links
- PubChem Compound
- 9351
- ChemSpider
- 8985
- ChEBI
- 31672
- ChEMBL
- CHEMBL542541
- Wikipedia
- Hydralazine
- Predicted Properties
Property Value Source Water Solubility 1.59 mg/mL ALOGPS logP 0.78 ALOGPS logP 0.83 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 10.98 Chemaxon pKa (Strongest Basic) 6.23 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 62.77 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 59.33 m3·mol-1 Chemaxon Polarizability 16.09 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon