Cefmenoxime hydrochlorideProduct ingredient for Cefmenoxime

Name
Cefmenoxime hydrochloride
Drug Entry
Cefmenoxime

Cefmenoxime is a novel broad-spectrum and third-generation cephalosporin antibiotic that is typically used in the treatment of female gynecologic and obstetric infections. It is reported to exhibit high activity against a wide variety of gram-positive and gram-negative bacteria.

Accession Number
DBSALT000801
Structure
Synonyms
Cefmenoxime HCl
UNII
NON736D32W
CAS Number
75738-58-8
Weight
Average: 548.019
Monoisotopic: 547.028154508
Chemical Formula
C16H18ClN9O5S3
InChI Key
HZYJYGJIOCXOTH-FAIYLGIWSA-N
InChI
InChI=1S/C16H17N9O5S3.ClH/c1-24-16(20-22-23-24)33-4-6-3-31-13-9(12(27)25(13)10(6)14(28)29)19-11(26)8(21-30-2)7-5-32-15(17)18-7;/h5,9,13H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29);1H/b21-8-;/t9-,13-;/m1./s1
IUPAC Name
(6R,7R)-7-{[(2Z)-1-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
SMILES
Cl.[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@@]2([H])N=C(O)C(=N/OC)\C1=CSC(=N)N1)C(O)=O
PubChem Compound
9690105
ChemSpider
7962939
ChEBI
775037
Wikipedia
Cefmenoxime
Predicted Properties
PropertyValueSource
Water Solubility1.56 mg/mLALOGPS
logP0.39ALOGPS
logP-1.2Chemaxon
logS-2.5ALOGPS
pKa (Strongest Acidic)2.58Chemaxon
pKa (Strongest Basic)9.84Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count12Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area191.27 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity146.82 m3·mol-1Chemaxon
Polarizability48.46 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon