Diphenylpyraline hydrochlorideProduct ingredient for Diphenylpyraline
- Name
- Diphenylpyraline hydrochloride
- Drug Entry
- Diphenylpyraline
Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.
- Accession Number
- DBSALT000807
- Structure
Structure for Diphenylpyraline hydrochloride (DBSALT000807)
- Synonyms
- 1-methyl-4-piperidyl benzhydryl ether hydrochloride / 1-methylpiperidyl-4-benzhydrylether hydrochloride / 4-(diphenylmethoxy)-1-methylpiperidine hydrochloride / Diphenylpyraline HCl
- UNII
- G9FU7F1E87
- CAS Number
- 132-18-3
- Weight
- Average: 317.853
Monoisotopic: 317.154642102 - Chemical Formula
- C19H24ClNO
- InChI Key
- LPRLDRXGWKXRMQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H
- IUPAC Name
- 4-(diphenylmethoxy)-1-methylpiperidine hydrochloride
- SMILES
- Cl.CN1CCC(CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- KEGG Drug
- D01172
- PubChem Compound
- 66063
- ChemSpider
- 59453
- ChEBI
- 31508
- ChEMBL
- CHEMBL1564
- Predicted Properties
Property Value Source Water Solubility 0.0188 mg/mL ALOGPS logP 3.82 ALOGPS logP 3.66 Chemaxon logS -4.2 ALOGPS pKa (Strongest Basic) 8.87 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 12.47 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 87.36 m3·mol-1 Chemaxon Polarizability 32.78 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon