Sertraline hydrochlorideProduct ingredient for Sertraline
- Name
- Sertraline hydrochloride
- Drug Entry
- Sertraline
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.
Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.6,10,19
- Accession Number
- DBSALT000808
- Structure
Structure for Sertraline hydrochloride (DBSALT000808)
- Synonyms
- (+)-cis-(1S,4S)-1-methylamino-4-(3,4-dichlorophenyl)tetralin hydrochloride / (+)-sertraline hydrochloride / (1S-cis)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride / (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-aminium chloride / Sertraline HCl
- UNII
- UTI8907Y6X
- CAS Number
- 79559-97-0
- Weight
- Average: 342.691
Monoisotopic: 341.050482702 - Chemical Formula
- C17H18Cl3N
- InChI Key
- BLFQGGGGFNSJKA-XHXSRVRCSA-N
- InChI
- InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
- IUPAC Name
- (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
- SMILES
- Cl.[H][C@@]1(CC[C@@]([H])(C2=CC(Cl)=C(Cl)C=C2)C2=CC=CC=C12)NC
- External Links
- KEGG Drug
- D00825
- PubChem Compound
- 63009
- ChemSpider
- 56707
- ChEBI
- 9124
- ChEMBL
- CHEMBL1709
- Wikipedia
- Sertraline
- Predicted Properties
Property Value Source Water Solubility 0.000145 mg/mL ALOGPS logP 5.06 ALOGPS logP 5.15 Chemaxon logS -6.3 ALOGPS pKa (Strongest Basic) 9.56 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 85.74 m3·mol-1 Chemaxon Polarizability 32.33 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon