Amantadine sulfateProduct ingredient for Amantadine
- Name
- Amantadine sulfate
- Drug Entry
- Amantadine
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
- Accession Number
- DBSALT000830
- Structure
Structure for Amantadine sulfate (DBSALT000830)
- Synonyms
- Not Available
- UNII
- 9921T5P019
- CAS Number
- 31377-23-8
- Weight
- Average: 400.58
Monoisotopic: 400.239578821 - Chemical Formula
- C20H36N2O4S
- InChI Key
- MYWTWSQFJLXGGQ-UHFFFAOYSA-N
- InChI
- InChI=1S/2C10H17N.H2O4S/c2*11-10-4-7-1-8(5-10)3-9(2-7)6-10;1-5(2,3)4/h2*7-9H,1-6,11H2;(H2,1,2,3,4)
- IUPAC Name
- bis(adamantan-1-amine); sulfuric acid
- SMILES
- OS(O)(=O)=O.NC12CC3CC(CC(C3)C1)C2.NC12CC3CC(CC(C3)C1)C2
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.0846 mg/mL ALOGPS logP 2.53 ALOGPS logP 1.47 Chemaxon logS -3.2 ALOGPS pKa (Strongest Basic) 10.71 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 26.02 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 45.54 m3·mol-1 Chemaxon Polarizability 17.92 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon