Pamidronate DisodiumProduct ingredient for Pamidronic acid
- Name
- Pamidronate Disodium
- Drug Entry
- Pamidronic acid
Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to neridronic acid and alendronic acid.2 Pamidronic acid was first described in the literature in 1977.9 The second generation bisphosphonates are less common as third generation bisphosphonates, such as ibandronic acid, zoledronic acid, minodronic acid, and risedronic acid are becoming more popular.2
Pamidronic acid was granted FDA approval on 31 October 1991.10
- Accession Number
- DBSALT000836
- Structure
Structure for Pamidronate Disodium (DBSALT000836)
- Synonyms
- Not Available
- UNII
- C7S8VWP5DH
- CAS Number
- 109552-15-0
- Weight
- Average: 279.0331
Monoisotopic: 278.964964021 - Chemical Formula
- C3H9NNa2O7P2
- InChI Key
- CEYUIFJWVHOCPP-UHFFFAOYSA-L
- InChI
- InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
- IUPAC Name
- disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate
- SMILES
- [Na+].[Na+].NCCC(O)(P(O)(O)=O)P([O-])([O-])=O
- External Links
- Predicted Properties
Property Value Source Water Solubility 41.9 mg/mL ALOGPS logP -1.2 ALOGPS logP -4.5 Chemaxon logS -0.82 ALOGPS pKa (Strongest Acidic) 0.67 Chemaxon pKa (Strongest Basic) 9.86 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 166.97 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 40.38 m3·mol-1 Chemaxon Polarizability 16.45 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon