Etidronate disodiumProduct ingredient for Etidronic acid
- Name
- Etidronate disodium
- Drug Entry
- Etidronic acid
Etidronic acid is a first generation bisphosphonate similar to clodronic acid and tiludronic acid.1 These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.4 Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.1
Etidronic acid was granted FDA approval on 1 September 1977.7
- Accession Number
- DBSALT000842
- Structure
- Synonyms
- (1-hydroxyethane-1,1-diyl)diphosphonic acid disodium salt / (1-hydroxyethylidene)diphosphonic acid, disodium salt / 1-hydroxyethylidene-1,1-diphosphonic acid disodium salt / disodium (1-hydroxyethylidene)diphosphonate / disodium 1-hydroxyethylidene phosphonate / disodium dihydrogen (1-hydroxyethylidene)diphosphonate / disodium ethane-1-hydroxy-1,1-diphosphonate / disodium ethanol-1,1-diphosphonate / Disodium ethydronate / Disodium etidronate / Etidronic acid disodium salt / Sodium ethidronate / Sodium ethydronate / Sodium etidronate
- UNII
- M16PXG993G
- CAS Number
- 7414-83-7
- Weight
- Average: 249.99
Monoisotopic: 249.93841509 - Chemical Formula
- C2H6Na2O7P2
- InChI Key
- GWBBVOVXJZATQQ-UHFFFAOYSA-L
- InChI
- InChI=1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
- IUPAC Name
- disodium hydrogen (1-hydrogen phosphonato-1-hydroxyethyl)phosphonate
- SMILES
- [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
- External Links
- KEGG Drug
- D00314
- PubChem Compound
- 23894
- ChemSpider
- 22339
- BindingDB
- 50247999
- ChEBI
- 4906
- ChEMBL
- CHEMBL1201042
- Wikipedia
- Etidronic_acid
- Predicted Properties
Property Value Source Water Solubility 38.3 mg/mL ALOGPS logP -0.39 ALOGPS logP -2.3 Chemaxon logS -0.81 ALOGPS pKa (Strongest Acidic) 0.7 Chemaxon pKa (Strongest Basic) -5.1 Chemaxon Physiological Charge -3 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 140.95 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 32.27 m3·mol-1 Chemaxon Polarizability 13.13 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon