Betamethasone sodium phosphateProduct ingredient for Betamethasone
- Name
- Betamethasone sodium phosphate
- Drug Entry
- Betamethasone
Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties.11 It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders.11 Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.11
- Accession Number
- DBSALT000850
- Structure
Structure for Betamethasone sodium phosphate (DBSALT000850)
- Synonyms
- Betamethasone disodium phosphate / Disodium betamethasone phosphate
- UNII
- 7BK02SCL3W
- CAS Number
- 151-73-5
- Weight
- Average: 516.41
Monoisotopic: 516.13012158 - Chemical Formula
- C22H28FNa2O8P
- InChI Key
- PLCQGRYPOISRTQ-LWCNAHDDSA-L
- InChI
- InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1
- IUPAC Name
- disodium (1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-14-[2-(phosphonatooxy)acetyl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one
- SMILES
- [Na+].[Na+].[H][C@]1(C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@]([H])(O)C[C@]2(C)[C@@]1(O)C(=O)COP([O-])([O-])=O
- External Links
- PubChem Compound
- 65478
- ChemSpider
- 58930
- ChEBI
- 3078
- ChEMBL
- CHEMBL1200762
- Wikipedia
- Betamethasone_phosphate
- Predicted Properties
Property Value Source Water Solubility 1.52 mg/mL ALOGPS logP 1.83 ALOGPS logP 1.56 Chemaxon logS -2.5 ALOGPS pKa (Strongest Acidic) 1.18 Chemaxon pKa (Strongest Basic) -3.4 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 147.02 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 111.12 m3·mol-1 Chemaxon Polarizability 44.94 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon