Triamcinolone diacetateProduct ingredient for Triamcinolone
- Name
- Triamcinolone diacetate
- Drug Entry
- Triamcinolone
Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis.13 Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,16 or first line as a topical treatment of corticosteroid responsive dermatoses.11 Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.10,11,12,13,14,15,16
Triamcinolone was granted FDA approval on 3 December 1957.9 In October 2021, a suspension of triamcinolone acetonide was approved for suprachoroidal injection - the first suprachoroidal injection to receive FDA approval19 - for the treatment of patients with macular edema associated with uveitis.18
- Accession Number
- DBSALT000859
- Structure
Structure for Triamcinolone diacetate (DBSALT000859)
- Synonyms
- Triamcinolone 16,21-diacetate / Triamcinolone diacetate
- UNII
- A73MM2Q32P
- CAS Number
- 67-78-7
- Weight
- Average: 478.513
Monoisotopic: 478.200296121 - Chemical Formula
- C25H31FO8
- InChI Key
- XGMPVBXKDAHORN-RBWIMXSLSA-N
- InChI
- InChI=1S/C25H31FO8/c1-13(27)33-12-20(31)25(32)21(34-14(2)28)10-18-17-6-5-15-9-16(29)7-8-22(15,3)24(17,26)19(30)11-23(18,25)4/h7-9,17-19,21,30,32H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22-,23-,24-,25+/m0/s1
- IUPAC Name
- 2-[(1S,2R,3aS,3bS,9aS,9bR,10S,11aS)-2-(acetyloxy)-9b-fluoro-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate
- SMILES
- [H][C@@]12C[C@@H](OC(C)=O)[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
- External Links
- KEGG Drug
- D00984
- KEGG Compound
- C08184
- PubChem Compound
- 6216
- ChemSpider
- 5981
- BindingDB
- 50247986
- ChEBI
- 9669
- ChEMBL
- CHEMBL1200449
- ZINC
- ZINC000003875441
- Wikipedia
- Triamcinolone_diacetate
- Predicted Properties
Property Value Source Water Solubility 0.0241 mg/mL ALOGPS logP 2.05 ALOGPS logP 1.12 Chemaxon logS -4.3 ALOGPS pKa (Strongest Acidic) 11.73 Chemaxon pKa (Strongest Basic) -3.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 127.2 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 117.69 m3·mol-1 Chemaxon Polarizability 48.44 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon