Metoprolol tartrateProduct ingredient for Metoprolol
- Name
- Metoprolol tartrate
- Drug Entry
- Metoprolol
Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.2,9 The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.5 To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.3 Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.8
- Accession Number
- DBSALT000862
- Structure
Structure for Metoprolol tartrate (DBSALT000862)
- Synonyms
- Not Available
- UNII
- W5S57Y3A5L
- CAS Number
- 56392-17-7
- Weight
- Average: 684.824
Monoisotopic: 684.383325251 - Chemical Formula
- C34H56N2O12
- InChI Key
- YGULWPYYGQCFMP-CEAXSRTFSA-N
- InChI
- InChI=1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; bis(1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol)
- SMILES
- [H][C@](O)(C(O)=O)[C@@]([H])(O)C(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1
- External Links
- PubChem Compound
- 441308
- ChemSpider
- 390070
- ChEBI
- 6906
- ChEMBL
- CHEMBL3186768
- Wikipedia
- Metoprolol
- Predicted Properties
Property Value Source Water Solubility 0.402 mg/mL ALOGPS logP 1.8 ALOGPS logP 1.76 Chemaxon logS -2.8 ALOGPS pKa (Strongest Acidic) 14.09 Chemaxon pKa (Strongest Basic) 9.67 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 50.72 Å2 Chemaxon Rotatable Bond Count 21 Chemaxon Refractivity 76.7 m3·mol-1 Chemaxon Polarizability 31.7 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon