Flupentixol dihydrochlorideProduct ingredient for Flupentixol
- Name
- Flupentixol dihydrochloride
- Drug Entry
- Flupentixol
Flupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid.1 Flupentixol is an antagonist of both D1 and D2 dopamine receptors.1
Available as oral tablets or long-acting intramuscular injections, flupentixol is marketed under brand names such as Depixol and Fluanxol. It is approved for use in Canada and other countries around the world, but not in the US. It is used for the management of chronic schizophrenia in patients whose main manifestations do not include excitement, agitation or hyperactivity.11 It has been marketed to manage symptoms of depression in patients who may or may not exhibit signs of anxiety.14 In combination with melitracen, flupentixol is used to manage symptoms of anxiety, depression, and asthenia.13
- Accession Number
- DBSALT000929
- Structure
Structure for Flupentixol dihydrochloride (DBSALT000929)
- Synonyms
- Flupentixol diHCl
- UNII
- 96L0Z069N1
- CAS Number
- 51529-01-2
- Weight
- Average: 507.44
Monoisotopic: 506.1173246 - Chemical Formula
- C23H27Cl2F3N2OS
- InChI Key
- IOVDQEIIMOZNNA-MHKBYHAFSA-N
- InChI
- InChI=1S/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;;/h1-2,4-8,16,29H,3,9-15H2;2*1H/b18-5-;;
- IUPAC Name
- 2-(4-{3-[(9Z)-2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethan-1-ol dihydrochloride
- SMILES
- Cl.Cl.OCCN1CCN(CC\C=C2\C3=CC=CC=C3SC3=CC=C(C=C23)C(F)(F)F)CC1
- External Links
- PubChem Compound
- 10140115
- ChemSpider
- 4445626
- ChEBI
- 180489
- ChEMBL
- CHEMBL1496351
- Predicted Properties
Property Value Source Water Solubility 0.00399 mg/mL ALOGPS logP 4.56 ALOGPS logP 4.5 Chemaxon logS -5 ALOGPS pKa (Strongest Acidic) 15.59 Chemaxon pKa (Strongest Basic) 8.03 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 26.71 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 128.17 m3·mol-1 Chemaxon Polarizability 45.71 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon