Dorzolamide hydrochlorideProduct ingredient for Dorzolamide
- Name
- Dorzolamide hydrochloride
- Drug Entry
- Dorzolamide
Dorzolamide is a non-bacteriostatic sulfonamide derivative 2 and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension.6 It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes.1 Unlike oral CA inhibitors, dorzolamide has negligible effects of acid-base or electrolyte disturbances and other systemic adverse effects.2 First marketed in 1995,5 dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt 6 or in combination with timolol as Cosopt PF.7
- Accession Number
- DBSALT000931
- Structure
Structure for Dorzolamide hydrochloride (DBSALT000931)
- Synonyms
- Dorzolamide HCl
- UNII
- QZO5366EW7
- CAS Number
- 130693-82-2
- Weight
- Average: 360.89
Monoisotopic: 360.0038983 - Chemical Formula
- C10H17ClN2O4S3
- InChI Key
- OSRUSFPMRGDLAG-QMGYSKNISA-N
- InChI
- InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1
- IUPAC Name
- (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1λ⁶-thieno[2,3-b]thiopyran-6-sulfonamide hydrochloride
- SMILES
- Cl.[H][C@]1(C)C[C@]([H])(NCC)C2=C(SC(=C2)S(N)(=O)=O)S1(=O)=O
- External Links
- PubChem Compound
- 6918132
- ChemSpider
- 5293345
- ChEBI
- 4703
- ChEMBL
- CHEMBL1201162
- Wikipedia
- Dorzolamide
- Predicted Properties
Property Value Source Water Solubility 0.699 mg/mL ALOGPS logP -0.5 ALOGPS logP -0.12 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) 8.16 Chemaxon pKa (Strongest Basic) 6.88 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 106.33 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 72.46 m3·mol-1 Chemaxon Polarizability 31.62 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon