Naproxen sodiumProduct ingredient for Naproxen

Show full entry for Naproxen
Name
Naproxen sodium
Drug Entry
Naproxen

Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.3 It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile.5 Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia.5 Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.12131516

See full entry for Naproxen
Accession Number
DBSALT000949
Structure
Similar Structures
Synonyms
Not Available
UNII
9TN87S3A3C
CAS Number
26159-34-2
Weight
Average: 252.245
Monoisotopic: 252.07623856
Chemical Formula
C14H13NaO3
InChI Key
CDBRNDSHEYLDJV-FVGYRXGTSA-M
InChI
InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
IUPAC Name
sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
SMILES
[Na+].[H][C@@](C)(C([O-])=O)C1=CC2=CC=C(OC)C=C2C=C1
PubChem Compound
23681059
ChemSpider
147912
ChEBI
7477
ChEMBL
CHEMBL1200806
Wikipedia
Naproxen
Predicted Properties
PropertyValueSource
Water Solubility0.0299 mg/mLALOGPS
logP3.39ALOGPS
logP2.99Chemaxon
logS-3.9ALOGPS
pKa (Strongest Acidic)4.19Chemaxon
pKa (Strongest Basic)-4.8Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area49.36 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity75.69 m3·mol-1Chemaxon
Polarizability24.43 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon