Sulfadimethoxine sodiumProduct ingredient for Sulfadimethoxine
- Name
- Sulfadimethoxine sodium
- Drug Entry
- Sulfadimethoxine
Sulfadimethoxine is a sulfonamide antibiotic. Sulfadimethoxine is used to treat many infections, including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved in some countries for use in humans. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. Sulfadimethoxine is approved in Russia for use in humans, including children, and has been successfully used there for more than 35 years. It is widely available in Russia as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies.
In the US, sulfadimethoxine is one of the products that have been withdrawn or removed from the market after being found to be unsafe or not effective.1
- Accession Number
- DBSALT000956
- Structure
Structure for Sulfadimethoxine sodium (DBSALT000956)
- Synonyms
- Not Available
- UNII
- 49DG2B481W
- CAS Number
- 1037-50-9
- Weight
- Average: 332.31
Monoisotopic: 332.05552037 - Chemical Formula
- C12H13N4NaO4S
- InChI Key
- DQDZQHMCPDUUPC-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H13N4O4S.Na/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9;/h3-7H,13H2,1-2H3;/q-1;+1
- IUPAC Name
- sodium 4-{[(2,6-dimethoxypyrimidin-4-yl)azanidyl]sulfonyl}aniline
- SMILES
- [Na+].COC1=CC([N-]S(=O)(=O)C2=CC=C(N)C=C2)=NC(OC)=N1
- External Links
- KEGG Compound
- C18386
- ChemSpider
- 64667
- ChEBI
- 81722
- ChEMBL
- CHEMBL2107253
- Predicted Properties
Property Value Source Water Solubility 1.72 mg/mL ALOGPS logP 1.12 ALOGPS logP 1.26 Chemaxon logS -2.3 ALOGPS pKa (Strongest Acidic) 6.91 Chemaxon pKa (Strongest Basic) 1.95 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 113.63 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 76.95 m3·mol-1 Chemaxon Polarizability 30.13 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon