Dextrothyroxine sodiumProduct ingredient for Dextrothyroxine
- Name
- Dextrothyroxine sodium
- Drug Entry
- Dextrothyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.
- Accession Number
- DBSALT001146
- Structure
Structure for Dextrothyroxine sodium (DBSALT001146)
- Synonyms
- Not Available
- UNII
- 0H00N2AHSP
- CAS Number
- 7054-08-2
- Weight
- Average: 816.871
Monoisotopic: 816.6792 - Chemical Formula
- C15H12I4NNaO5
- InChI Key
- ANMYAHDLKVNJJO-CURYUGHLSA-M
- InChI
- InChI=1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m1../s1
- IUPAC Name
- sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate hydrate
- SMILES
- O.[Na+].N[C@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C([O-])=O
- External Links
- ChemSpider
- 61909
- ChEMBL
- CHEMBL3545058
- Wikipedia
- Dextrothyroxine
- Predicted Properties
Property Value Source Water Solubility 0.00688 mg/mL ALOGPS logP 4.54 ALOGPS logP 3.73 Chemaxon logS -5.1 ALOGPS pKa (Strongest Acidic) 0.27 Chemaxon pKa (Strongest Basic) 9.43 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 95.61 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 137.63 m3·mol-1 Chemaxon Polarizability 49.03 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon