Proguanil hydrochlorideProduct ingredient for Proguanil
- Name
- Proguanil hydrochloride
- Drug Entry
- Proguanil
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
- Accession Number
- DBSALT001187
- Structure
Structure for Proguanil hydrochloride (DBSALT001187)
- Synonyms
- Proguanil HCl
- UNII
- R71Y86M0WT
- CAS Number
- 637-32-1
- Weight
- Average: 290.19
Monoisotopic: 289.086101 - Chemical Formula
- C11H17Cl2N5
- InChI Key
- SARMGXPVOFNNNG-UHFFFAOYSA-N
- InChI
- InChI=1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
- IUPAC Name
- 1-[N'-(4-chlorophenyl)carbamimidamido]-N-(propan-2-yl)methanimidamide hydrochloride
- SMILES
- Cl.CC(C)NC(=N)NC(=N)NC1=CC=C(Cl)C=C1
- External Links
- ChemSpider
- 4514300
- ChEMBL
- CHEMBL1201059
- Wikipedia
- Proguanil
- Predicted Properties
Property Value Source Water Solubility 0.116 mg/mL ALOGPS logP 2.29 ALOGPS logP 2.38 Chemaxon logS -3.3 ALOGPS pKa (Strongest Basic) 10.4 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 83.79 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 91.65 m3·mol-1 Chemaxon Polarizability 26.75 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon