Hydrocodone bitartrateProduct ingredient for Hydrocodone
- Name
- Hydrocodone bitartrate
- Drug Entry
- Hydrocodone
Hydrocodone is a synthetic opioid derivative of codeine.14 It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.17
- Accession Number
- DBSALT001233
- Structure
- Synonyms
- Not Available
- UNII
- NO70W886KK
- CAS Number
- 34195-34-1
- Weight
- Average: 988.987
Monoisotopic: 988.389986329 - Chemical Formula
- C44H64N2O23
- InChI Key
- JMBRWJAVUIITGV-LNNMZZBZSA-N
- InChI
- InChI=1S/2C18H21NO3.2C4H6O6.5H2O/c2*1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;2*5-1(3(7)8)2(6)4(9)10;;;;;/h2*3,6,11-12,17H,4-5,7-9H2,1-2H3;2*1-2,5-6H,(H,7,8)(H,9,10);5*1H2/t2*11-,12+,17-,18-;2*1-,2-;;;;;/m0011...../s1
- IUPAC Name
- bis((1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one) bis((2R,3R)-2,3-dihydroxybutanedioic acid) pentahydrate
- SMILES
- O.O.O.O.O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.COC1=C2O[C@H]3C(=O)CC[C@H]4[C@H]5CC(C=C1)=C2[C@@]34CCN5C.COC1=C2O[C@H]3C(=O)CC[C@H]4[C@H]5CC(C=C1)=C2[C@@]34CCN5C
- External Links
- ChemSpider
- 21864751
- ChEBI
- 5780
- Wikipedia
- Hydrocodone
- Predicted Properties
Property Value Source Water Solubility 0.797 mg/mL ALOGPS logP 2.13 ALOGPS logP 1.96 Chemaxon logS -2.6 ALOGPS pKa (Strongest Acidic) 18 Chemaxon pKa (Strongest Basic) 8.61 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 38.77 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 82.74 m3·mol-1 Chemaxon Polarizability 32.02 Å3 Chemaxon Number of Rings 10 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon