Oxymorphone hydrochlorideProduct ingredient for Oxymorphone
- Name
- Oxymorphone hydrochloride
- Drug Entry
- Oxymorphone
An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). On June 8, 2017, FDA requested Endo Pharmaceuticals to remove the medication from the market due to opioid misuse and abuse risks associated with the product's injectable reformulation.
- Accession Number
- DBSALT001249
- Structure
Structure for Oxymorphone hydrochloride (DBSALT001249)
- Synonyms
- Oxymorphone HCl
- UNII
- 5Y2EI94NBC
- CAS Number
- 357-07-3
- Weight
- Average: 337.8
Monoisotopic: 337.1080858 - Chemical Formula
- C17H20ClNO4
- InChI Key
- BCGJBQBWUGVESK-KCTCKCTRSA-N
- InChI
- InChI=1S/C17H19NO4.ClH/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9;/h2-3,12,15,19,21H,4-8H2,1H3;1H/t12-,15+,16+,17-;/m1./s1
- IUPAC Name
- (1S,5R,13R,17S)-10,17-dihydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one hydrochloride
- SMILES
- Cl.CN1CC[C@]23[C@H]4OC5=C(O)C=CC(C[C@@H]1[C@]2(O)CCC4=O)=C35
- External Links
- ChemSpider
- 4514272
- ChEBI
- 7866
- ChEMBL
- CHEMBL1200794
- Wikipedia
- Oxymorphone
- Predicted Properties
Property Value Source Water Solubility 25.6 mg/mL ALOGPS logP 1.26 ALOGPS logP 0.78 Chemaxon logS -1.1 ALOGPS pKa (Strongest Acidic) 10.07 Chemaxon pKa (Strongest Basic) 8.21 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 70 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 79.56 m3·mol-1 Chemaxon Polarizability 30.74 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon