Latamoxef disodiumProduct ingredient for Latamoxef
- Name
- Latamoxef disodium
- Drug Entry
- Latamoxef
Latamoxef is a broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
- Accession Number
- DBSALT001335
- Structure
- Synonyms
- Latamoxef sodium / Moxalactam disodium / Moxalactam sodium
- External IDs
- LY-127935
- UNII
- 5APW73W3QZ
- CAS Number
- 64953-12-4
- Weight
- Average: 564.44
Monoisotopic: 564.06513592 - Chemical Formula
- C20H18N6Na2O9S
- InChI Key
- GRIXGZQULWMCLU-HUTAOCTPSA-L
- InChI
- InChI=1S/C20H20N6O9S.2Na/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9;;/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32);;/q;2*+1/p-2/t12?,18-,20+;;/m1../s1
- IUPAC Name
- disodium (6R,7R)-7-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- SMILES
- [Na+].[Na+].[H][C@]12OCC(CSC3=NN=NN3C)=C(N1C(=O)[C@]2(NC(=O)C(C([O-])=O)C1=CC=C(O)C=C1)OC)C([O-])=O
- External Links
- ChemSpider
- 390015
- ChEMBL
- CHEMBL1200357
- Predicted Properties
Property Value Source Water Solubility 1.54 mg/mL ALOGPS logP 1.27 ALOGPS logP 0.17 Chemaxon logS -2.6 ALOGPS pKa (Strongest Acidic) 2.81 Chemaxon pKa (Strongest Basic) -1.7 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 12 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 211.96 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 155.38 m3·mol-1 Chemaxon Polarizability 46.42 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon