Bepridil hydrochlorideProduct ingredient for Bepridil

Name
Bepridil hydrochloride
Drug Entry
Bepridil

A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).

Accession Number
DBSALT001436
Structure
Synonyms
Bepridil HCl
UNII
4W2P15D93M
CAS Number
74764-40-2
Weight
Average: 421.02
Monoisotopic: 420.2543561
Chemical Formula
C24H37ClN2O2
InChI Key
UEECHQPWQHYEDE-UHFFFAOYSA-N
InChI
InChI=1S/C24H34N2O.ClH.H2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H;1H2
IUPAC Name
N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline hydrate hydrochloride
SMILES
O.Cl.CC(C)COCC(CN(CC1=CC=CC=C1)C1=CC=CC=C1)N1CCCC1
ChemSpider
82825
ChEBI
52715
ChEMBL
CHEMBL1200382
Wikipedia
Bepridil
Predicted Properties
PropertyValueSource
Water Solubility0.00655 mg/mLALOGPS
logP5.33ALOGPS
logP5.49Chemaxon
logS-4.8ALOGPS
pKa (Strongest Basic)9.16Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area15.71 Å2Chemaxon
Rotatable Bond Count10Chemaxon
Refractivity115.12 m3·mol-1Chemaxon
Polarizability43.79 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon