Valganciclovir hydrochlorideProduct ingredient for Valganciclovir
- Name
- Valganciclovir hydrochloride
- Drug Entry
- Valganciclovir
Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
- Accession Number
- DBSALT001459
- Structure
Structure for Valganciclovir hydrochloride (DBSALT001459)
- Synonyms
- Valganciclovir HCl
- UNII
- 4P3T9QF9NZ
- CAS Number
- 175865-59-5
- Weight
- Average: 390.83
Monoisotopic: 390.1418456 - Chemical Formula
- C14H23ClN6O5
- InChI Key
- ZORWARFPXPVJLW-MTFPJWTKSA-N
- InChI
- InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
- IUPAC Name
- 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate hydrochloride
- SMILES
- Cl.CC(C)[C@H](N)C(=O)OCC(CO)OCN1C=NC2=C1NC(N)=NC2=O
- External Links
- ChemSpider
- 99298
- ChEMBL
- CHEMBL1200454
- Wikipedia
- Valganciclovir
- Predicted Properties
Property Value Source Water Solubility 4.79 mg/mL ALOGPS logP -0.81 ALOGPS logP -0.69 Chemaxon logS -1.9 ALOGPS pKa (Strongest Acidic) 11.98 Chemaxon pKa (Strongest Basic) 7.48 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 167.08 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 86.6 m3·mol-1 Chemaxon Polarizability 34.88 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon